DNA-based asymmetric catalysis
نویسندگان
چکیده
منابع مشابه
DNA-based asymmetric catalysis.
The unique chiral structure of DNA has been a source of inspiration for the development of a new class of bio-inspired catalysts. The novel concept of DNA-based asymmetric catalysis, which was introduced only five years ago, has been applied successfully in a variety of catalytic enantioselective reactions. In this tutorial review, the ideas behind this novel concept will be introduced, an over...
متن کاملDeciphering DNA-based asymmetric catalysis through intramolecular Friedel-Crafts alkylations.
We describe asymmetric intramolecular Friedel-Crafts alkylations with a DNA-based hybrid catalyst and propose a plausible binding model. This study shows promise for studying relationships between the helical chirality of DNA and enantioselectivity of the chemical reaction.
متن کاملDNA-Based Asymmetric Catalysis: Role of Ionic Solvents and Glymes.
Recently, DNA has been evaluated as a chiral scaffold for metal complexes to construct so called 'DNA-based hybrid catalysts', a robust and inexpensive alternative to enzymes. The unique chiral structure of DNA allows the hybrid catalysts to catalyze various asymmetric synthesis reactions. However, most current studies used aqueous buffers as solvents for these asymmetric reactions, where subst...
متن کاملOrganic co-solvents in aqueous DNA-based asymmetric catalysis.
Water-miscible organic co-solvents can be used in DNA-based catalytic asymmetric reactions at appreciable concentration without a negative effect on enantioselectivity. While the rate of the copper(II) Diels-Alder reaction is affected negatively by the presence of organic co-solvents, the copper(II) catalyzed Michael addition and Friedel-Crafts alkylation reaction are significantly faster. Addi...
متن کاملLigand denticity controls enantiomeric preference in DNA-based asymmetric catalysis.
DNA-based catalysis can be used to control the enantioselectivity of copper-catalysed Diels-Alder and Friedel-Crafts reactions to produce either enantiomer of the product by changing the denticity of the ligand coordinated to the Cu(II) ion, even though the DNA adopts a right handed helical conformation only.
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ژورنال
عنوان ژورنال: Chemical Society Reviews
سال: 2010
ISSN: 0306-0012,1460-4744
DOI: 10.1039/b811349c